Plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum
نویسندگان
چکیده
منابع مشابه
Fusarium graminearum Tri12p influences virulence to wheat and trichothecene accumulation.
The gene Tri12 encodes a predicted major facilitator superfamily protein suggested to play a role in export of trichothecene mycotoxins produced by Fusarium spp. It is unclear, however, how the Tri12 protein (Tri12p) may influence trichothecene sensitivity and virulence of the wheat pathogen Fusarium graminearum. In this study, we establish a role for Tri12 in toxin accumulation and sensitivity...
متن کاملComparison of Trichothecene Biosynthetic Gene Expression between Fusarium graminearum and Fusarium asiaticum
Nivalenol (NIV) and deoxynivalenol (DON) are predominant Fusarium-producing mycotoxins found in grains, which are mainly produced by Fusarium asiaticum and F. graminearum. NIV is found in most of cereals grown in Korea, but the genetic basis for NIV production by F. asiaticum has not been extensively explored. In this study, 12 genes belonging to the trichothecene biosynthetic gene cluster were...
متن کاملBiochemistry and Regulation of Trichothecene Toxin Biosynthesis in Fusarium
The trichothecenes are a large family of sesquiterpene epoxides that inhibit eukaryotic protein synthesis and thereby impairhuman and animal health. Several fungal species of the genus Fusarium and related generacan produce trichothecenes in agricultural crops and commodities. Interest in these toxins is due primarily to the discovery that trichothecene contamination ofhuman foods and animal fe...
متن کاملThe bZIP Transcription Factor Fgap1 Mediates Oxidative Stress Response and Trichothecene Biosynthesis But Not Virulence in Fusarium graminearum
Redox sensing is of primary importance for fungi to cope with oxidant compounds found in their environment. Plant pathogens are particularly subject to the oxidative burst during the primary steps of infection. In the budding yeast Saccharomyces cerevisiae, it is the transcription factor Yap1 that mediates the response to oxidative stress via activation of genes coding for detoxification enzyme...
متن کاملBiosynthesis of trichothecene mycotoxins in Fusarium culmorum cultures.
A high yielding production of the trichothecene mycotoxin 3-acetyldeoxynivalenol (3-AcDON) in cultures of Fusarium culmorum is described. By supplying [14C]acetate, 14C-labelled 3-AcDON suitable for further metabolic studies has been obtained. The pattern of labelling has been ascertained by using 13C-labelled acetate precursors, and is in line with established biosynthetic data. A second trich...
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ژورنال
عنوان ژورنال: Letters in Applied Microbiology
سال: 2014
ISSN: 0266-8254
DOI: 10.1111/lam.12250